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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
《医学前沿(英文)》 2019年 第13卷 第4期 页码 427-437 doi: 10.1007/s11684-018-0672-6
关键词: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
《医学前沿(英文)》 2022年 第16卷 第1期 页码 17-24 doi: 10.1007/s11684-021-0873-2
Personalized medicine of type 2 diabetes
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 1-3 doi: 10.1007/s11684-013-0241-y
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 480-489 doi: 10.1007/s11684-017-0594-8
Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.
关键词: human immunodeficiency virus type I superinfection incidence immune response
Metabolomics in human type 2 diabetes research
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 4-13 doi: 10.1007/s11684-013-0248-4
The high prevalence of diabetes and diabetic complications has caused a huge burden on the modern society. Although scientific advances have led to effective strategies for preventing and treating diabetes over the past several decades, little progress has been made toward curing the disease or even getting it under control, from a public health and overall societal standpoint. There is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetes and different drug responses, highlighting the need for the development of early diagnostic and prognostic markers for diabetes and diabetic complications. The emergence of metabolomics has allowed researchers to systemically measure the small molecule metabolites, which are sensitive to the changes of both environmental and genetic factors and therefore, could be regarded as the link between genotypes and phenotypes. During the last decade, the progression made in metabolomics has provided insightful information on disease development and disease onset prediction. Recent studies using metabolomics approach coupled with statistical tools to predict incident diabetes revealed a number of metabolites that are significantly altered, including branched-chain and aromatic amino acids, such as isoleucine, leucine, valine, tyrosine and phenylalanine, as diagnostic or highly-significant predictors of future diabetes. This review summarizes the current findings of metabolomic studies in human investigations with the most common form of diabetes, type 2 diabetes.
关键词: metabolomics type 2 diabetes metabolic pathway mass spectrometry nuclear magnetic resonance (NMR)
《结构与土木工程前沿(英文)》 2021年 第15卷 第4期 页码 1071-1071 doi: 10.1007/s11709-021-0736-6
The mechanisms linking adiposopathy to type 2 diabetes
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《医学前沿(英文)》 2013年 第7卷 第4期 页码 433-444 doi: 10.1007/s11684-013-0288-9
Obesity is defined as excessive accumulation of body fat in proportion to body size. When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathy. Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseases. In overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic islet and liver and induces pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type 2 diabetes. Moreover, adipokines have been shown to play important roles in the regulation of glucose homeostasis. When adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the development and progression of pancreatic β cell dysfunction and insulin resistance in peripheral tissue. The current paper briefly discusses the latest findings regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type 2 diabetes.
Mechanical performance analysis and stiffness test of a new type of suspension bridge
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1160-1180 doi: 10.1007/s11709-021-0760-6
关键词: new type of suspension bridge stiffness test mechanical performance railway bridge space truss
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
《能源前沿(英文)》 2009年 第3卷 第4期 页码 414-422 doi: 10.1007/s11708-009-0038-5
关键词: axial-type fan gradient method free-vortex method design variable total pressure static pressure operating flowrate
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 497-504 doi: 10.1007/s11783-011-0256-z
关键词: 13X-type zeolite CO oxidation gold solution pH calcination temperature
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
《医学前沿(英文)》 2008年 第2卷 第2期 页码 195-199 doi: 10.1007/s11684-008-0037-7
关键词: chemotactic activity receptor uPA inhibitor F10 chemoattractant
Coulomb-type solutions for passive earth pressure with steady seepage
WANG Junjie, CHAI Hejun, LIN Xin, XU Jiamei
《结构与土木工程前沿(英文)》 2008年 第2卷 第1期 页码 56-66 doi: 10.1007/s11709-008-0001-2
关键词: function coefficient Coulomb-type effective friction different drainage
《医学前沿(英文)》 2022年 第16卷 第1期 页码 126-138 doi: 10.1007/s11684-021-0897-7
关键词: type 2 diabetes quality of care macrovascular complication microvascular complication treatment pattern epidemiology
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 94-100 doi: 10.1007/s11684-011-0116-z
Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality. Bone marrow is the traditional source of human MSC, but human term placenta appears to be an alternative and more readily available source. Here, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patients with longer duration, islet cell dysfunction, high insulin doses as well as poor glycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type 2 diabetes (T2D). Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion. The total number of PDSC for each patient was (1.22–1.51) × 106/kg, with an average of 1.35 × 106/kg. All of the patients were followed up after therapy for at least 3 months. A daily mean dose of insulin used in 10 patients was decreased from 63.7?±?18.7 to 34.7?±?13.4 IU (P<0.01), and the C-peptide level was increased from 4.1?±?3.7 ng/mL to 5.6?±?3.8 ng/mL (P<0.05) respectively after therapy. In 4 of 10 responders their insulin doses reduced more than 50% after infusion. The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment (P<0.05). No fever, chills, liver damage and other side effects were reported. The renal function and cardiac function were improved after infusion. The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple, safe and effective therapeutic approach for T2D patients with islet cell dysfunction. Further large-scale, randomized and well-controlled clinical studies will be required to substantiate these observations.
Tahereh R. BASTAMI,Mohammad H. ENTEZARI,Chiwai KWONG,Shizhang QIAO
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 378-385 doi: 10.1007/s11705-014-1441-y
关键词: spinel type polymeric surfactant size evolution mangnetic ferrite nanoparticle
标题 作者 时间 类型 操作
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
期刊论文
Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:
null
期刊论文
Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and
期刊论文
Development of an axial-type fan with an optimization method
Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,
期刊论文
Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity
Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG
期刊论文
Chemotactic effect of urokinase-type plasminogen activator on mouse spermatozoa
DING Xiaofang, LI Honggang, XIONG Chengliang
期刊论文
Coulomb-type solutions for passive earth pressure with steady seepage
WANG Junjie, CHAI Hejun, LIN Xin, XU Jiamei
期刊论文
Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai
期刊论文
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
null
期刊论文